Montmorillonite Nanocomposite Hydrogel Based on Poly(acrylicacid-co-acrylamide): Polymer Carrier for Controlled Release Systems
نویسندگان
چکیده مقاله:
In this paper, the synthesis of new montmorillonite nanocomposite hydrogel (MMTNH) based on poly (acrylic acid-co-acrylamide) grafted onto starch, is described. Montmorillonite (MMT) as nanometer base, acrylic acid (AA) and acrylamide (AAm) as monomers, ammonium persulfate (APS) as an initiator, N,N-methylenebisacrylamide (MBA) as a crosslinker and starch as a biocompatible polymer were prepared in aqueous solution and their amounts were optimized to attain the highest water absorbance. The optimized swelling capacity in distilled water was found to be 810 g/g. A mechanism for hydrogel formation was proposed and the structure of the product was confirmed using a set of techniques including FT-IR spectroscopy, thermogravimetric analysis, scanning electron microscopy, transmission electron microscopy, atomic force microscopy, and X-ray powder diffraction. Furthermore, the swelling behaviors of the nanocomposite at different pHs, various salt with different concentrations, the mixture of solvents, were investigated. The methylene blue (MB) dye was used as model drugs to assess the loading and release by MMTNH. The pH response of this MMTNH makes it suitable for acting as a controlled delivery system. The results suggest MMTNH may find applications as promising drug delivery vehicles for drug molecules.
منابع مشابه
pH Sensitive Hydrogel Based Acrylic Acid for Controlled Drug Release
Hydrogels, due to their unique potentials such as high-water content and hydrophilicity are interest for the controlled release of drug molecules. The present study aims to create a controlled-release system through the preparation and characterization of hydrogels based on pH-sensitive polymers such as poly (acrylic acid). Poly (acrylic acid), p(AA), hydrogel has been synthesized by radical po...
متن کاملMagnetic/pH-sensitive nanocomposite hydrogel based carboxymethyl cellulose –g- polyacrylamide/montmorillonite for colon targeted drug delivery
Objective(s): The main aim of current research was to develop a novel magnetically responsive hydrogel by radical polymerization of carboxymethyl cellulose (CMC) on acryl amide (Am) using N,N'-methylene bis acrylamide (MBA) as a crosslinking agent, potassium persulfate (KPS) as a free radical initiator, and magnetic montmorillonite ( mMT) nanoclay as nano-...
متن کاملph sensitive hydrogel based acrylic acid for controlled drug release
hydrogels, due to their unique potentials such as high-water content and hydrophilicity are interest for the controlled release of drug molecules. the present study aims to create a controlled-release system through the preparation and characterization of hydrogels based on ph-sensitive polymers such as poly (acrylic acid). poly (acrylic acid), p(aa), hydrogel has been synthesized by radical po...
متن کاملConducting Polymer- Hydrogel Blends for Electrochemically Controlled Drug Release Devices
Blendas formadas pela polimerização eletroquímica de pirrol em matriz de acrilamida (hidrogel) foram utilizadas, neste trabalho, como dispositivos para a liberação controlada de drogas. A influência de vários parâmetros nesta síntese, como tipo de matriz de hidrogel e condições de polimerização, foi estudada empregando-se planejamento fatorial fracionário. O objetivo final consistiu na obtenção...
متن کاملMagnetic/pH-sensitive nanocomposite hydrogel based carboxymethyl cellulose-g-polyacrylamide/montmorillonite for colon targeted drug deliver
* Corresponding Author Email: [email protected] Objective(s): The main aim of current research was to develop a novel magnetically responsive hydrogel by radical polymerization of carboxymethyl cellulose (CMC) on acryl amide (Am) using N,N'-methylene bis acrylamide (MBA) as a crosslinking agent, potassium persulfate (KPS) as a free radical initiator, and magnetic montmorillonite ( mMT)...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ذخیره در منابع من قبلا به منابع من ذحیره شده{@ msg_add @}
عنوان ژورنال
دوره 38 شماره 5
صفحات 31- 43
تاریخ انتشار 2019-10-01
با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023